Lecturer in Cancer Biology
I am a Lecturer in Cancer Biology in the School of Medicine here at the University and maintain guest researcher status at Newcastle University.
I am a University of Sunderland alumni, after graduating with a distinction in Biomedical Science in 2018. During this time, I completed a research project which sparked my interest in cancer research.
To specialise further in the field of cancer research, I chose to complete an MRes in Cancer at Newcastle University. My research project investigated the role of glycosylation enzymes responsible for adding sialic acid to the cell surface of prostate cancer. Upon completion, I worked as a research technician within the Newcastle Fibrosis Research Group where I developed my laboratory skillset, performing several immunoassays and precision cut tissue slicing of solid organs. Combining my immunological and glycobiology knowledge, I selected a PhD project in the field of prostate cancer glycoimmunology at Newcastle University. My project investigated sialoglycan-Siglec interactions within the prostate cancer tumour immune microenvironment. Following successful obtainment of my PhD, I continued to work within the glycoimmunology team as a Post Doctoral Research Associate before joining the University of Sunderland as a Lecturer in Cancer Biology.
My research interest continues to surround the interplay between immunoinhibitory receptors (Siglecs) found on the surface of immune cells and sialic acid hyper expressed on tumour cells, and the potential to target this to improve treatment response for patients. I continue to work closely with Newcastle University on research projects and would welcome interest from self-funded PhD and summer project students.
Teaching and supervision
Phase 1 MBChB Medicine.
Research interests for potential research students
- Investigating sialic acid-Siglec interactions within the prostate cancer tumour immune microenvironment
- Targeting sialic acid-Siglec interactions to improve response rates to cancer immunotherapy
Research
- PhD research project: Investigating the sialoglycan-Siglec axis in the prostate cancer tumour immune microenvironment.
Publications
Article
Hodgson, Kirsty, Orozco-Moreno, Margarita, Goode, Emily Archer, Fisher, Matthew, Garnham, Rebecca, Beatson, Richard, Turner, Helen, Livermore, Karen, Zhou, Yuhan, Wilson, Laura, Visser, Eline A, Pijnenborg, Johan FA, Eerden, Nienke, Moons, Sam J, Rossing, Emiel, Hysenaj, Gerald, Krishna, Rashi, Peng, Ziqian, Nangkana, Kyla Putri, Schmidt, Edward N, Duxfield, Adam, Dennis, Ella P, Heer, Rakesh, Lawson, Michelle A, Macauley, Matthew, Elliott, David J, Büll, Christian, Scott, Emma, Boltje, Thomas J, Drake, Richard R, Wang, Ning and Munkley, Jennifer (2024) Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone. eBioMedicine, 104 (105163). ISSN 2352-3964
Garnham, Rebecca, Geh, Daniel, Nelson, Ryan, Ramon-Gil, Erik, Wilson, Laura, Schmidt, Edward N, Walker, Laura, Adamson, Beth, Buskin, Adriana, Hepburn, Anastasia C, Hodgson, Kirsty, Kendall, Hannah, Frame, Fiona M, Maitland, Norman, Coffey, Kelly, Strand, Douglas W, Robson, Craig N, Elliott, David J, Heer, Rakesh, Macauley, Matthew, Munkley, Jennifer, Gaughan, Luke, Leslie, Jack and Scott, Emma (2024) ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer. Communications Biology, 7. ISSN 2399-3642
Hodgson, Kirsty, Orozco-Moreno, Margarita, Scott, Emma, Garnham, Rebecca, Livermore, Karen, Thomas, Huw D, Zhou, Yuhan, He, Jiepei, Bermudez, Abel, Marques, Fernando Jose Garcia, Bastian, Kayla, Hysenaj, Gerald, Goode, Emily Archer, Heer, Rakesh, Pitteri, Sharon, Wang, Ning, Elliott, David J and Munkley, Jennifer (2023) The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer. Scientific Reports, 13 (1). p. 211. ISSN 2045-2322
Scott, Emma, Goode, Emily Archer, Garnham, Rebecca, Hodgson, Kirtsy, Orozco-Moreno, Margarita, Turner, Helen, Livermore, Karen, Kyla, Nangkana Putri, Fiona, Frame M, Bermudez, Abel, Marques, Fernando Jose Garcia, McClurg, Urszula L, Wilson, Laura, Thomas, Huw, Buskin, Adriana, Hepburn, Anastasia, Duxfield, Adam, Bastian, Kayla, Pye, Hayley, Arredondo, Hector M, Hysenaj, Gerald, Heavey, Susan, Stopka-Farooqui, Urszula, Haider, Aiman, Freeman, Alex, Singh, Saurabh, Johnston, Edward W, Punwani, Shonit, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Harries, Lorna, Heer, Rakesh, Maitland, Norman J, Whitaker, Hayley, Pitteri, Sharon, Troyer, Dean A, Wang, Ning, Elliott, David J, Drake, Richard R and Munkley, Jennifer (2023) ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression. Journal of Pathology, 261 (1). pp. 71-84. ISSN 1096-9896
Alebady, Zainab A H, Azizyan, Mahsa, Nakjang, Sirintra, Nakjang, Sirintra, Lishman-Walker, Emma, Al-Kharaif, Dhuha, Walker, Scott, Choo, Hui Xian, Garnham, Rebecca, Scott, Emma, Johnson, Katya L, Robson, Craig N and Coffey, Kelly (2023) CDC20 Is Regulated by the Histone Methyltransferase, KMT5A, in Castration-Resistant Prostate Cancer. Cancers, 15 (14). p. 211. ISSN 2072-6694
Alebady, Zainab A H, Azizyan, Mahsa, Nakjang, Sirintra, Lishman-Walker, Emma, Al-Kharaif, Dhuha, Choo, Hui Xian, Garnham, Rebecca, Scott, Emma, Johnson, Katya L, Robson, Craig N and Coffey, Kelly (2023) CDC20 is regulated by the histone methyltransferase, KMT5A, in castration resistant prostate cancer. Preprints.org.
Garnham, Rebecca, Geh, Daniel, Nelson, Ryan, Ramon-Gill, Erik, Wilson, Laura, Schmidt, Edward N, Walker, Laura, Adamson, Beth, Buskin, Adriana, Hepburn, Anastasia, Hodgson, Kirsty, Kendall, Hannah, Frame, Fiona M, Maitland, Norman, Coffey, Kelly, Robson, Craig N, Elliott, David J, Heer, Rakesh, Macauley, Matthew, Munkley, Jennifer, Gaughan, Luke, Leslie, Jack and Scott, Emma (2023) ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer. bioRxiv.
Scott, Emma, Hodgson, Kirsty, Calle, Beatriz, Turner, Helen, Cheung, Kathleen, Bermudez, Abel, Marques, Fernando Jose Garcia, Pye, Hayley, Yo, Edward Christopher, Islam, Khirul, Oo, Htoo Zarni, McClurg, Urszula L, Wilson, Laura, Thomas, Huw, Frame, Fiona M, Orozco-Moreno, Margarita, Bastian, Kayla, Arredondo, Hector M, Roustan, Chloe, Gray, Melissa Anne, Kelly, Lois, Tolson, Aaron, Mellor, Ellie, Hysenaj, Gerald, Goode, Emily Archer, Garnham, Rebecca, Duxfield, Adam, Heavey, Susan, Stopka-Farooqui, Urszula, Haider, Aiman, Freeman, Alex, Singh, Saurabh, Johnston, Edward W., Shonit, Punwani, Knight, Bridget, Paul, McCullagh, McGrath, John, Crundwell, Malcolm, Harries, Lorna, Bogdan, Denisa, Westaby, Daniel, Fowler, Gemma, Flohr, Penny, Yuan, Wei, Sharp, Adam, Bono, Johann de, Maitland, Norman J, Wisnovsky, Simon, Bertozzi, Carolyn R., Heer, Rakesh, Guerrero, Ramon Hurtado, Daugaard, Mads, Leivo, Janne, Whitaker, Hayley, Pitteri, Sharon, Wang, Ning, Elliott, David J, Schumann, Benjamin and Munkley, Jennifer (2023) Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Oncogene, 42. pp. 926-937. ISSN 0950-9232
Munkley, Jennifer, Scott, Emma, Hodgson, Kirsty, Calle, Beatriz, Turner, Helen, Cheung, Kathleen, Bermudez, Abel, Marques, Fernando, Pye, Hayley, Yo, Edward Christopher, Islam, Khirul, Oo, Htoo Zarni, McClurg, Urszula L, Wilson, Laura, Thomas, Huw, Frame, Fiona M, Orozco-Moreno, Margarita, Bastian, Kayla, Arredondo, Hector M, Roustan, Chloe, Gray, Melissa Anne, Kelly, Lois, Tolson, Aaron, Mellor, Ellie, Hysenaj, Gerald, Goode, Emily Archer, Garnham, Rebecca, Duxfield, Adam, Heavey, Susan, Stopka-Farooqu, Urszula, Haider, Aiman, Freeman, Alex, Singh, Saurabh, Johnston, Edward W., Punwani, Shonit, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Bogdan, Denisa, Harries, Lorna, Westaby, Daniel, Fowler, Gemma, Flohr, Penny, Yuan, Wei, Sharp, Adam, DeBono, Johann, Maitland, Norman, Wisnovsky, Simon, Bertozzi, Carolyn, Heer, Rakesh, Guerrero, Ramon Hurtado, Daugaard, Mads, Leivo, Janne, Whitaker, Hayley, Pitteri, Sharon, Wang, Ning, Elliott, David and Schumann, Benjamin (2022) Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Research Square. ISSN 2693-5015
Scott, Emma, Garnham, Rebecca, Cheung, Kathleen, Duxfield, Adam, Elliott, David and Munkley, Jennifer (2022) Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer. International Journal of Molecular Sciences, 23 (15). ISSN Extracellular Interactors of the IGF System: Impact on Cancer Hallmarks and Therapeutic Approaches Extracellular Interactors of the IGF System: Impact on Cancer Hallmarks and Therapeutic Approaches The Relationship between Circadian Rhythm a
Scott, Emma, Garnham, Rebecca, Cheung, Kathleen, Duxfield, Adam, Elliott, David and Munkley, Jennifer (2022) Pro-survival factor EDEM3 confers therapy resistance in prostate cancer. Research Square.
Garnham, Rebecca, Scott, Emma, Livermore, Karen E and Munkley, Jennifer (2019) ST6GAL1: A key player in cancer. Oncology Letters, 18 (2). pp. 211-989. ISSN 1792-1074
- Cancer immunology
- Prostate cancer
- Immunotherapies
- Glycobiology