Associate Professor of Analytical Pharmacology
I am a pharmacologist and a qualified veterinary surgeon (non-practising). I have over 30 years of experience teaching pharmacology to medical, veterinary, pharmacy, and science students. I previously worked as a research pharmacologist at AstraZeneca on the project that discovered the anti-platelet drugs ticagrelor and cangrelor.
My primary academic interest is in drug action; I teach pharmacology to our medical students and conduct pharmacological research. I have a particular interest in drugs that affect platelet function. I also have a keen interest in the statistical analysis and modelling of laboratory data, as well as issues in medical and bio-ethics.
Teaching and supervision
In the School of Medicine, I teach and advise on all aspects of pharmacology on MBChB Medicine. I also supervise student SSC projects.
In addition, I am a personal tutor, I assist with interviewing candidates applying for medicine and contribute to the writing, reviewing, and assessment of exam questions.
Previous responsibilities include:
- Academic Lead for Year 2, Unit 12 on cardiovascular medicine
- Timetabling Lead for the School of Medicine
- PBL tutor for Year 1 and year 2 medical students
- Lectures on medical statistics and data analysis
Research interests for potential research students
I am interested in the action of drugs on platelets. Recent projects include investigations into the mechanism of action of citalopram and Bcl-2 inhibitors on platelets, and also the use of 'big data' algorithms to identify novel anti-platelet activity in commonly used drugs.
Research
Platelet Pharmacology and Drug Discovery
Platelets are small blood cells that are responsible for stopping bleeding following injury. They can also contribute to thrombosis and lead to heart attacks and strokes. Aspirin is widely used to reduce the risk of these cardiovascular diseases and works by reducing platelet activity. Aspirin is beneficial in these conditions but is not completely effective and has well-known side effects. I have studied the action of drugs on platelets for over 30 years. During this time I was involved in the discovery of the novel anti-platelet drugs, ticagrelor and cangrelor. Ticagrelor is now used in the clinic and is often used alongside aspirin: dual antiplatelet therapy.
I am also interested in drugs that may affect platelet function as a side effect. Citalopram is a widely used antidepressant but at high concentrations can affect platelet function. Together with my graduate student, Harvey Roweth, our research identified novel mechanisms of anti-platelet action of citalopram.
Other projects have included the characterisation of the platelet-activating properties of Bcl-2 inhibitors and the use of big data algorithms to identify novel anti-platelet activity in commonly used drugs.
Publications
Article
Marton, Akos, Ahmed, Shahzaib, Jarvis, Gavin E., Brassett, Ceclia, Grant, Ian and Gaunt, Michael E (2022) The Berrettini palmar neural communicating branch: a study of 27 cadaveric specimens and determination of a high-risk surgical zone. Journal of Hand Surgery (European Volume), 47 (8). pp. 851-856. ISSN 1753-1934
Feitsma, Louris J., Brondijk, Harma C., Jarvis, Gavin E., Hagemans, Dominique, Bihan, Dominique, Jerah, Natasia, Versteeg, Marian, Farndale, Richard W. and Huizinga, Eric G. (2022) Structural insights into collagen binding by platelet receptor glycoprotein VI. Blood, 139 (20). pp. 3087-3098. ISSN 0006-4971
Haseler, Callum J., Jarvis, Gavin E. and McGovern, Kate F. (2021) Intrasynovial triamcinolone treatment is not associated with incidence of acute laminitis. Equine Veterinary Journal, 53 (5). pp. 895-901. ISSN 0425-1644
Mullins, William, Jarvis, Gavin E., Oluboyede, Daniel, Skingle, Linda, Poole, Ken, Turmezei, Tom and Brassett, Cecilia (2020) The Segond fracture occurs at the site of lowest sub‐entheseal trabecular bone volume fraction on the tibial plateau. Journal of Anatomy, 237 (6). pp. 1040-1048. ISSN 0021-8782
Jarvis, Gavin E. (2020) Misjudging early embryo mortality in natural human reproduction. F1000Research, 9. p. 702. ISSN 2046-1402
Jarvis, Gavin E. (2020) Misjudging early embryo mortality in natural human reproduction. F1000 Research, 9. p. 702. ISSN 2046-1402
Roweth, Harvey G, Cook, Aaron A, Moroi, Masaaki, Bonna, Arkadiusz M, Jung, Stephanie M, Bergmeier, Wolfgang, Sage, Stewart O and Jarvis, Gavin E. (2018) Two novel, putative mechanisms of action for citalopram-induced platelet inhibition. Scientific reports, 8 (1). p. 16677. ISSN 2045-2322
Roweth, Harvey G, Yan, Ruoling, Bedwani, Nader H, Chauhan, Alisha, Fowler, Nicole, Watson, Alice H, Malcor, Jean-Daniel, Sage, Stewart O and Jarvis, Gavin E. (2018) Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport. Scientific reports, 8 (1). p. 3494. ISSN 2045-2322
Jarvis, Gavin E. (2017) Early embryo mortality in natural human reproduction: What the data say. F1000 Research, 5. p. 2765. ISSN 2046-1402
Jarvis, Gavin E., Evans, R J and Heath, M F (1996) The role of ADP in endotoxin-induced equine platelet activation. European journal of pharmacology, 315 (2). pp. 203-12. ISSN 0014-2999
Conference or Workshop Item
Talks, Charles, Brady, Robert, Jarvis, Gavin E., Brassett, Cecilia, Vivian, Anthony and Somner, John (2024) Investigation of anatomical variation in the superior oblique tendon and its clinical significance. In: BACA Summer Scientific Meeting 2024, 02 Jul 2024, Keele University, UK. (Unpublished)
Nayak, Siddhant, Dowell, John, Grainger, Andrew, Jarvis, Gavin E., Ashwood, Neil and Brassett, Cecilia (2024) Morphological variation of Lister’s tubercle and its association with the Extensor Pollicis Longus tendon. In: BACA Summer Scientific Meeting 2024, 02 Jul 2024, Keele University, UK. (Unpublished)
Jarvis, Gavin E., Newman, H, Elhakeem, O I, Al-Shahrani, M, Gkoutos, G V, Hoehndorf, R and Schofield, P N (2022) Surfing the PHOME for Novel Anti-Platelet Agents: Empirical Evaluation of a Bioinformatic Drug Re-Purposing Algorithm. In: 30th Congress of the International Society on Thrombosis and Haemostasis, July 9-13, 2022, London. (Submitted)
Jarvis, Gavin E. (2021) Editors’ Moral Obligations – Profit, Regulation and Virtue. In: 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11), 23-28 Aug 2021, Maastricht (held online).
Other
Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Beuve, Annie, Brouckaert, Peter, Bryant, Clare, Burnett, John C., Farndale, Richard W., Friebe, Andreas, Garthwaite, John, Hobbs, Adrian J., Jarvis, Gavin E., Kuhn, Michaela, MacEwan, David, Monie, Tom P., Papapetropoulos, Andreas, Potter, Lincoln R., Schmidt, Harald H.H.W., Szabo, Csaba and Waldman, Scott A. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. Wiley.
- Pharmacology
- Drug use
Academic publishing:
- Editorial Board Member for Scientific Reports
- Statistical Adviser to Platelets
- Section Editor (Biostatistics and Experimental Design) for Laboratory Animals